The Hancock County Sheriff's Office said it happened early Sunday morning at 1:11 a.m. on County Road 18, between Township Road 215 and County Road 216, northeast of Findlay in Cass Township.
The occupants on the plane, a male pilot and a female passenger, were pronounced dead at the scene, according to authorities. Their identities have not been released as of this time.
They had been traveling in a small, Lancair airplane from Holland, Mich., to Bluffton, Ohio.
Officials continue to block off the intersection as officials investigate what caused the crash.