The closures come amid continued attempts by Republican lawmakers to restrict abortions and also at a time when abortions have slightly increased in the state.
The Columbus Dispatch reports Wednesday the state Department of Health last week rejected an appeal to stay open by the Lebanon Road Surgery Center in Sharonsville in southwest Ohio.
That decision followed September's closure of the Cleveland Center for Women's Health.
Capital Care Network of Toledo remains open while it appeals a state closure order because it does not have a transfer agreement with a hospital in case of complications from an abortion procedure.
Toledo's other abortion clinic, Center for Choice, closed in June for similar reasons.
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