White House officials confirmed Biden plans to visit the CSX Northwest Ohio Intermodal Terminal in North Baltimore Wednesday.
The Northwest Ohio Terminal in North Baltimore employs about 300 people and manages more than 30 trains a day, according to its website.
It is known as the cornerstone of the National Gateway that connects the Midwest and Mid-Atlantic regions.
The terminal recevies support as a federal, state and private investment.
U.S. Secretary of Transportation Anthony Foxx also is expected to be on hand as Biden talks about the importance of investing in infrastructure.
(AP contributed to this report.)